Natural killer (NK) cells are innate immune lymphocytes capable of rapidly responding to
tumors and infection without prior sensitization. There is increasing interest and success in
harnessing NK cell function for the treatment of disease, in particular cancers. NK cell
activation is dependent on integration of signals through cytokine and germline-encoded
activating and inhibitory receptors. The availability of metabolic fuels and pathways is
required for NK effector functions including proliferation, killing, and production of interferon …